李小妹

一、个人简介
李小妹,1988年出生,基础医学院,副教授,硕士生导师;入选莆田市高层次人才第四类人才;主持国家自然科学基金青年科学基金项目1项,福建省自然基金青年创新项目1项,莆田市科技计划项目1项;主要研究成果刊登于《Cell Death & Differentiation》、《Molecular Carcinogenesis》等国内外学术期刊,其中SCI收录8篇,中文CSCD核心1篇;获莆田学院2022年度“科研先进个人”称号。主要研究方向:从事泛素介导的蛋白质降解在疾病进展等方面研究。
教育经历:
2017.09-2021.06厦门大学,博士,生理学
2011.09-2014.06福建师范大学,硕士,生物化学与分子生物学
工作经历:
2023.01-至今莆田学院,基础医学院,副教授
2021.08-2022.12莆田学院,基础医学院,讲师
2015.07-2017.09莆田学院附属医院,中心实验室,科研人员
2014.07-2015.04中国科学研究院广州能源研究所,能源化工实验室,研究助理
联系方式:18450050730,邮箱:xmlee0104@163.com
二、科研项目
研究项目
1.“去泛素化酶USP39通过调控Wnt/β-catenin信号通路促进肝脏再生的机制研究”,国家自然科学基金青年科学基金项目,2023-2025,主持,30万;
2. “去泛素化酶USP39通过EZH2调控脂肪沉积在非酒精性脂肪肝中的作用及机制研究”,福建省自然基金青年创新项目,2022-2025,主持,8万;
3. “USP39通过去泛素化调控β-catenin/c-Myc表达进而促进肝癌进展的机制研究”,2021年度莆田学院引进人才科研启动费项目,2021-2024,主持,10万;
4. “USP39 通过去泛素化 EZH2 调控 CCNB1 促进肝癌进展的机制研究”,莆田市科技计划项目,2023-2026,主持,7万;
三、科研成果
论文著作
1. Rong Zeng#, Xiaomei Li#, Fangfei Wang, Jinliang Xie, Conghua Song, Yong Xie.Reinforced medication adherence improves Helicobacter pylori eradication rate in developing countries: A systematic review and meta-analysis of randomized controlled trials. [J]. Helicobacter. 2023;28:e12989.
2. Xiaomei Li#, Jiahui Yuan#, Conghua Song, Yongbin Lei, Jiajia Xu, Gongye Zhang, Weiwei Wang, Gang Song*. Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma. [J]. Cell Death and Differentiation, 2021 Aug;28(8):2315-2332.
3. Jiahui Yuan#, Xiaomei Li#, Gongye Zhang, Weipeng Cheng, Weiwei Wang, Yongbin Lei, Qiujuan Ma, Gang Song*. USP39 mediates p21-dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis. Molecular Carcinogenesis. 2021 Apr; 60(4):265-278.
4. Xiaomei Li#, Rongxian Qiu#, Conghua Song#, Qinghua Huang, Xiaodong Wang, Zhenting Hu, Xiongzhi He, Xiangyang Ye, Xiaogang Huang, Fengfeng Zheng, Guoxian Lin*.Genotype and genetic variation of HCV infections with low-risk factors in Putian coastal regions, China. Epidemiology and Infection, 2017, Dec;145(16): 3385-3397.
5. Jiahui Yuan, Gongye Zhang, Xiaomei Li,Qiujuan Ma, Weipeng Cheng, Weiwei Wang, Bing Zhang, Tianhui Hu, Gang Song*. Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway [J]. International Journal of Molecular Sciences, 2020, Nov 25; 21(23): 8949.
6. Xiaomei Li#, Conghua Song#, Lian Xiong, Xuefang Chen, Chao Huang, Xiaoqing Lin, Xinde Chen*, Microbial Conversion of Wastewater from Butanol Fermentation to Microbial Oil and Biomass by Oleaginous Yeasts. Environmental Progress & Sustainable Energy, 2018, 37(3): 1220-1226.
7. Lin Chen#, Xiaomei Li#, Mingzi Wang, Jian Huang, Bilian Chen*, Xinglong Li, Xing Zheng, Utilization of gaseous emissions from a methanol plant for cultivation of Acutodesmus obliquus. Journal of Applied Phycology, 2016, 28: 2661–2669.
8. Xiaomei Li, Lian Xiong, Xuefang Chen, Chao Huang, Xinde Chen*, Longlong Ma, Effects of Acetic Acid on Growth and Lipid Productionby Cryptococcus albidus. Journal of the American Oil Chemists' Society, 2015, 92: 1113–1118;
9. Xiaomei Li, Mingzi Wang, Xinhui Liao, Han Chen, Youfen Dai, Bilian Chen*, Two Stages of N‑Deficient Cultivation Enhance the Lipid Contentof Microalga Scenedesmus sp. Journal of the American Oil Chemists' Society, 2015, 92: 503–512;
10. 李小妹,廖兴辉, 王明兹, 陈必链*. 两步培养法提高栅藻的生物量及油脂含量[J]. 中国油脂, 2014, 39(5), 53-56.