
一、个人简介
邹汉勋,1986年出生,副教授,硕士生导师(资源与环境、生物与医药专业)。博士毕业于中国科学院大学有机化学专业,先后就职于新加坡眼科研究所和中国科学院福建物质结构研究所,2023年9月以高层次人才引进至莆田学院环境与生物工程学院工作,入选福建省高层次人才(C类)。主要从事超分子化学、有机荧光探针和生物传感与疾病诊疗等方面研究工作。近年来在Journal of the American Chemical Society、CCS Chemistry,Journal Of Medicinal Chemistry、Chinese Chemical Letters、ACS Applied Materials & Interfaces和Organic Chemistry Frontiers等国内外高水期刊发表论文近30篇,申请国内、国际专利9项;目前主持国家自然科学基金一项,福建省自然科学基金一项。
教育经历:
2017.09-2020.09中国科学院大学博士有机化学
2009.09-2012.06 华南理工大学硕士有机化学
2005.09-2009.06 青岛大学本科化学
工作经历:
2023.09-至今莆田学院环境与生物工程学院副教授
2016.02-2023.08中国科学院福建物质结构研究所助理研究员
2012.07-2016.01新加坡眼科研究所助理研究员
联系方式:hanxun_zou@163.com
二、科研项目
1.基于动态共价化学的近红外二区发光组装体构筑及调控研究,国家自然科学基金青年项目,22101283,2022-01至2024-12,30万元,在研,主持
2. 比率型近红外二区荧光示踪的肿瘤诊疗前药构建及其精准响应控释研究,福建省自然科学基金面上项目,2024J01131012,2024-05至2027-04,10万元,在研,主持
3. 高反应性比率型近红外二区荧光探针设计及其在肝癌诊断的应用探索,莆田学院交叉学科专项-工科/医科,ZY240096,2024-07至2027-07,5万元,在研,主持
三、科研成果
论文著作
(1) L. Wang, #H. Zou, # H. Ye, Y. Hai, H. Lu, J., Deng, L. You*. Photoswitchable Molecular Recognition Enabled by Dithienylethene-Mediated Structural Changes of Dynamic Covalent Hydrazone Bonds. CCS Chemistry, 2024, 6, 497-506. (中国科学院一区,IF = 11.2).
(2) G. Jiang, L. Wang, H. Ye, H. Zou*, L. You*. Dynamic Covalent Reactions and Chirality Sensing with Diphenylethene Derived Hemiaminals. ChemPlusChem, 2023, e202300080. (中国科学院三区, IF = 3.21)
(3) S. Qin, H. Zou*, Y. Hai, L. You*. Aggregation-induced emission luminogens and tunable multicolor polymer networks modulated by dynamic covalent chemistry. Chin. Chem. Lett.2022, 33, 3267-3271. (中国科学院一区,IF = 8.455)
(4) Z. She, H. Zou*, L. You*. Tuning the selectivity of amino acid recognition with dynamic covalent bond constrained fluorophores in aqueous media. Org. Biomol. Chem. 2022, 20, 6897-6904. (中国科学院三区,IF = 3.89)
(5) F. Sattar, Z. Feng, H. Zou*, H. Ye, Y. Zhang*, L. You*. Dynamic covalent bond constrained ureas for multimode fluorescence switching, thermally induced emission, and chemical signaling cascades. Org. Chem. Front. 2021, 8, 3760-3769. (中国科学院一区,IF = 5.456)
(6) I. Khan, J. Wang, H. Zou*, H. Ye, D. Zha, Y. Zhang*, L. You*. Noncovalent and dynamic covalent chemistry strategies fordriving thermoresponsive phase transition with multistimuli andControlled Encapsulation/Release. ACS Appl. Mater. Interfaces,2020, 12, 2962−2973.(中国科学院二区,IF = 10.383)
(7) H. Zou,# Y. Hai,# H. Ye, L. You*. Dynamic covalent cwitches and communicating networks for tunable multicolor luminescent systems and vapor-responsive materials. J. Am. Chem. Soc. 2019, 141, 41, 16344-16353. (中国科学院一区,IF = 15.0)
(8) Y. Hai,#H. Zou,#H. Ye, L. You*. Three switchable orthogonal dynamic covalent reactions andcomplex networks based on the control of dual reactivity. J. Org. Chem.2018, 83, 9858−9869.(中国科学院二区,IF = 4.198)
(9) J. -J. Koh,#H. Zou,# S. Lin, H. Lin, R. T. Soh, F. H. Lim, W. Luan Koh, J. Li, R. Lakshminarayanan, C. Verma, D. T. H. Tan, D. Cao*, R. Beuerman*, S. Liu*; Nonpeptidic amphiphilic xanthone derivatives: structure-activity relationship and membrane-targeting properties , J. Med. Chem., 2016, 59, 171-193. (中国科学院一区,IF = 8.039)
(10) H. Zou,# J.-J. Koh,# J. Li, S. Qiu, T. T. Aung, H. Lin, R. Lakshminarayanan, X. Dai, C. Tang, F. H. Lim, L. Zhou, A. L. Tan, C. Verma, D. T. H. Tan, H. S. O. Chan, P. Saraswathi, D. Cao*, S. Liu*, R. Beuerman*; Design and synthesis of amphiphilic xanthone-based, membrane-targeting antimicrobials with improved membrane selectivity, J. Med. Chem., 2013, 56, 2359-2373.(中国科学院一区,IF = 8.039)
(11) C. Yin,#H. Ye,# Y. Hai, H. Zou,L. You*. Aromatic-Carbonyl Interactions as an Emerging Type of Non-Covalent Interactions. Adv. Sci.2024, doi.org/10.1002/advs.202310337.(中国科学院一区,IF = 15.1)
(12) H. Lu, H. Ye, M. Zhang, Z. Liu, H. Zou, L. You*. Photoswitchable dynamic conjugate addition-elimination reactions as a tool for light-mediated click and clip chemistry. Nat. Commun.2023,14, 4015.(中国科学院一区,IF = 16.6)
(13) C. Yin, H. Lu, H. Ye, Z. Feng, H. Zou, M. Zhang and L. You*. Double n→π* Interactions with One Electron Donor: Structural and Mechanistic Insights. Org. Lett.2023, 25, 1470−1475. (中国科学院一区,IF = 5.2)
(14)Q. Hu, Y. Liu, W. Li, Y. Wang, W. Liao, H. Zou, J. Li*, X. Huang*. Enhanced photocatalytic hydrogen evolution under visible-light using C, N Co-doped mesoporous TiO2 nanocrystals templated by ionic liquids.Chem. Eng. J. 2023, 451, 138670. (中国科学院一区,IF = 15.1)
(15)Y. Hai, H. Ye, Z. Li, H. Zou, H. Lu, and L. You*. Light-induced formation/scission of C-N, C-O, and C-S bonds enables switchable stability/degradability in covalent systems.J. Am. Chem. Soc. 2021, 143, 20368–20376.(中国科学院一区,IF = 15.0)
知识产权
(1)Hanxun Zou, Rajamani Lakshminarayanan, Lei Zhou,Chang chuiCharles Tang, Jun-Jie Koh, Donald Tan, Chandra Verma, Roger W. Beuerman,Shouping Liu,Padmanabhan Saraswath. Derivatives of Xanthone Compounds. Pub. No.:WO/2013/036207; International Application No.: PCT/SG2012/000328.(已授权)
(2) 尤磊、邹汉勋、叶何波.一种荧光开关及其制备方法、应用。专利号:201910092023.2 (已授权)
(3)尤磊、海宇、叶何波、邹汉勋、陆涵葳、李紫毅. 二噻吩乙烯内酯类化合物以及制备、光调控方法。专利号:202110184683.0(已授权)
(4) 尤磊、姜国山、海宇、邹汉勋、环链异构二苯乙烯荧光分子以及制备方法、应用。专利号:202110184903.X(已授权)
(5) 尤磊、海宇、叶何波、邹汉勋、陆涵葳、李紫毅. 一种芳基乙烯内酯类化合物及其制备方法、应用。专利号:202110471450.9
(6) 尤磊、邹汉勋、冯泽林、陆涵葳. 一种脲化合物其制备方法、应用。专利号:202110443727.7
(7)尤磊、邹汉勋、张翼. 一种基于1,8-萘二甲酰亚胺的水溶性荧光探针及其制备方法和应用。专利号:201910246470.9
(8)尤磊、陆涵葳、叶何波、章梅兰、邹汉勋.一种2-(乙氧基亚甲基)1,3-二酮二噻吩乙烯衍生物及其制备方法和应用。专利号:202210948443.8
(9)尤磊、陆涵葳、叶何波、章梅兰、邹汉勋。一种二噻吩乙烯1,3-二酮化合物及其制备方法、应用。专利号:202210947333.X
个人荣誉
2022年获“福建省高层次人才(C类)”荣誉称号