陆德婵，研究方向是新型SERS纳米生物传感器的构建及应用研究。目前主要围绕肿瘤体外诊断生物标志物、肿瘤诊断功能化纳米新材料、新方法开展研究，并取得良好的研究进展。熟练具备纳米材料合成制备，生物组织样品处理，多元数据统计分析等核心科研能力。目前以第一作者发表SCI论文10篇，授权发明专利4件。主持莆田学院人才引进启动基金项目、福建省中青年教师教育科研项目科技类重点项目、医工交叉项目。参与国家自然科学基金面上项目，省自然科学基金项目，福建省卫健委科技计划项目等。
联系电话：18149544204 电子邮箱：DechanLu@163.com
一、教学及科研业绩情况
代表性论著：
1.Lu Dechan., Chen Yanping., Ke Longfeng., Wu Weilin., Yuan Liwen., Feng Shangyuan., Huang Zufang., Lu Yudong., Wang Jing. Machine learning-assisted global DNA methylation fingerprint analysis for differentiating early-stage lung cancer from benign lung diseases. Biosens Bioelectron. 2023;235: 115235.2.
2. Lu Dechan., Zhang Bohan., Shangguan Zhikun., Lu Yudong., Chen Jingbo., Huang Zufang., Machine learning-based exosome profiling of multi-receptor SERS sensors for differentiating adenocarcinoma in situ from early-stage invasive adenocarcinoma.
Colloids Surf B Biointerfaces. 2024;236: 113824.
3. Lu Dechan., Shangguang Zhikun., Su Zhehao., Lin Chuan., Huang Zufang., Xie Haihe., Artificial intelligence-based plasma exosome label-free SERS profiling strategy for early lung cancer detection. Anal Bioanal Chem (2024). https://doi.org/10.1007/s00216-024-05445-z
4.Lu Dechan., Chen Cairou., Xu Peipei., You Ruiyun., Lu Zhenzhen., Lu Yudong. Two-dimensional substrate assisted SERS immunosensor for accurate detection of carcinoembryonic antigen. Spectrochim Acta A Mol Biomol Spectrosc. 2023;302: 123142.3.
5.Lu Dechan, Cai Rongyuan, Liao Yuqin, You Ruiyun, Lu Yudong. Two-dimensional glass/p-ATP/Ag NPs as multifunctional SERS substrates for label-free quantification of uric acid in sweat. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2023;296: 122631.4.
6.Lu Dechan., Zhang Qun., Huang Zufang., Lu Yudong., Feng Shangyuan., You Ruiyun., Li Minling., Zhang Shaoqin. Ratiometric SERS quantitative analysis of tyrosinase activity based on gold-gold hybrid nanoparticles with Prussian blue as an internal standard. Colloids Surf B Biointerfaces. 2022;217: 112645.
7.Lu Dechan., Lin Xueliang., Chen Cairou., Lu Yudong., Feng Shangyuan., Huang Zufnag., You Ruiyun., Chen Jingbo., Wu Yang. Interference-free SERS tags for ultrasensitive quantitative detection of tyrosinase in human serum based on magnetic bead separation. Anal Chim Acta. 2020;1138: 150-157.6.
8.Lu Dechan., Fan Min., Cai Rongyuan., Huang Zufang., You Ruiyun., Huang Luqiang., Feng Shangyuan., Lu Yudong. Silver nanocube coupling with a nanoporous silver film for dual-molecule recognition based ultrasensitive SERS detection of dopamine. Analyst. 2020;145: 3009-3016.7.
9.Lu Dechan#., Zhang Bohan., You Ruiyun, Chen Jingbo., Machine learning-assisted internal standard calibration label-free SERS strategy for colon cancer detection. Anal Bioanal Chem. 2023;415: 1699-1707.8.
10. Gao Feng#, Lu Dechan#, Zheng Tianlei, Geng Shi, Sha Juncheng, Huang Ouyang, Tang Liangjie, Zhu Peiwu, Li Yangyang, Chen Lili, Targher Giovanni, Byrne Christopher D., Huang Zufang, Zheng Minghua, consortium Chess-Mafld. Fully connected neural network-based serum surface-enhanced Raman spectroscopy accurately identifies non-alcoholic steatohepatitis. Hepatology International. 2022.
授权专利：
1.陆德婵；翁婷炜；卢玉栋；黄祖芳；朱兰瑾；一种基于AuPB@Au NPs荧光检测酪氨酸酶的方法，2020-03-17，中国，ZL2020101878521（专利）
2.陆德婵；陈彩柔；卢玉栋；黄祖芳；刘显鹏；沈慧英；一种用于检测酪氨酸酶活性的SERS基底及利用该基底检测酪氨酸酶活性的方法，2020-02-17，中国，ZL2020100966671（专利）
3.陆德婵; 许慧瑶; 卢玉栋; 沈慧英; 吴阳; 陈玉婷; 一种双分子识别多巴胺表面增强拉曼传感 器的制备及应用，2019-01-11，中国，ZL2018112229363（专利）
4.陆德婵；先丽；卢玉栋；翁婷炜；沈慧英；吴阳；朱兰瑾；陈玉婷；一种用于检测酪氨酸酶的三明治结构SERS传感器及其制备和检测方法，2019-04-25，中国，ZL2019103372155（专利）
承担教学及科研项目：
1. 基于SERS光谱技术的肺癌早期诊断的分子标志物的筛选，2023134，莆田学院人才引进启动基金，2024/1-2026/12, 30万，主持。
2. 基于多受体传感器的肺癌外泌体识别技术，福建省中青年教师教育科研项目科技类重点项目，JZ230043, 2024/1-2026/12, 10万，主持。
所获荣誉
福建省C类人次
莆田学院紫霄人才
