邹汉勋教师个人简介
邹汉勋，讲师，1986年出生，福建省高层次人才（C类），博士毕业于中国科学院大学有机化学专业，先后就职于新加坡眼科研究所和中国科学院福建物质结构研究所。2023年9月以高层次人才引进到莆田学院环境与生物工程学院工作。主要从事有机超分子化学、有机光功能材料和药物化学等相关领域的研究。近年来，在Journal of the American Chemical Society、CCS Chemistry，Journal Of Medicinal Chemistry、Chinese Chemical Letters、ACS Applied Materials & Interfaces和Organic Chemistry Frontiers等国内外高水期刊发表论文20余篇，申请国内、国际专利9项；主持国家自然科学基金一项，参与完成国家自然科学基金委、中国科学院和福建省重点项目多项。
研究方向
（1）刺激响应性有机发光材料的设计、合成和应用研究
（2）基于超分子化学和动态共价化学的可控自组装材料的研究
（3）新型医用材料的合成与应用探索
教育背景
2005.09-2009.06 青岛大学化学专业，本科，化学专业
2009.09-2012.06 华南理工大学有机化学专业，硕士，有机化学专业，导师：曹德榕 教授
2017.09-2020.09 中国科学院大学，博士，有机化学专业，导师：尤磊 研究员
工作经历
2012.07-2016.01 新加坡眼科研究所（Singapore Eye Research Institute，）
2016.05-2023.08 中国科学院福建物质结构研究所
2023.09-至今 莆田学院环境与生物工程学院
研究项目
（1）国家自然科学基金委员会，青年项目，22101283，基于动态共价化学的近红外二区发光组装体构筑及调控研究，2022-01至2024-12，30万元，在研，主持。
（2）闽都创新实验室主任基金项目，主任基金，392021ZR112，基于动态共价聚合物的柔性自修复发光材料，2021-03至2023-02，30万元，已结题，参与。
（3）国家自然科学基金委员会，面上项目，21672214，基于氮杂环鎓盐的新型动态共价键和复杂动态信号级联体系，2017-01至2020-12，65万元，已结题，参与。
（4）中国科学院，前沿科学重点研究项目，QYZBD-SSW-SLH030，动态共价键、组装及其导向的传感和标记功能研究，2016-07至2021-06，250万元，已结题，参与。
已发表论文
(1) H. Zou,# Y. Hai,# H. Ye, L. You*. Dynamic covalent cwitches and communicating networks for tunable multicolor luminescent systems and vapor-responsive materials. J. Am. Chem. Soc. 2019, 141, 41, 16344-16353. （中国科学院一区，IF = 16.383）
(2) L. Wang, # H. Zou, # H. Ye, Y. Hai, H. Lu, J., Deng, L. You*. Photoswitchable Molecular Recognition Enabled by Dithienylethene-Mediated Structural Changes of Dynamic Covalent Hydrazone Bonds. CCS Chemistry, 2023, / 10.31635/ccschem.023.202302893. （中国化学会旗舰期刊，IF = 11.2）.
(3) I. Khan, J. Wang, H. Zou*, H. Ye, D. Zha, Y. Zhang*, L. You*. Noncovalent and dynamic covalent chemistry strategies for driving thermoresponsive phase transition with multistimuli and Controlled Encapsulation/Release. ACS Appl. Mater. Interfaces, 2020, 12, 2962−2973. （中国科学院二区，IF = 10.383）
(4) S. Qin, H. Zou*, Y. Hai, L. You*. Aggregation-induced emission luminogens and tunable multicolor polymer networks modulated by dynamic covalent chemistry. Chin. Chem. Lett. 2022, 33, 3267-3271. （中国科学院一区，IF = 8.455）
(5) Z. She, H. Zou*, L. You*. Tuning the selectivity of amino acid recognition with dynamic covalent bond constrained fluorophores in aqueous media. Org. Biomol. Chem. 2022, 20, 6897-6904. （中国科学院三区，IF = 3.89）
(6) F. Sattar, Z. Feng, H. Zou*, H. Ye, Y. Zhang*, L. You*. Dynamic covalent bond constrained ureas for multimode fluorescence switching, thermally induced emission, and chemical signaling cascades. Org. Chem. Front. 2021, 8, 3760-3769. （中国科学院一区，IF = 5.456）
(7) J. -J. Koh,# H. Zou,# S. Lin, H. Lin, R. T. Soh, F. H. Lim, W. Luan Koh, J. Li, R. Lakshminarayanan, C. Verma, D. T. H. Tan, D. Cao*, R. Beuerman*, S. Liu*; Nonpeptidic amphiphilic xanthone derivatives: structure-activity relationship and membrane-targeting properties , J. Med. Chem., 2016, 59, 171-193. （中国科学院一区，IF = 8.039）
(8) H. Zou,# J.-J. Koh,# J. Li, S. Qiu, T. T. Aung, H. Lin, R. Lakshminarayanan, X. Dai, C. Tang, F. H. Lim, L. Zhou, A. L. Tan, C. Verma, D. T. H. Tan, H. S. O. Chan, P. Saraswathi, D. Cao*, S. Liu*, R. Beuerman*; Design and synthesis of amphiphilic xanthone-based, membrane-targeting antimicrobials with improved membrane selectivity, J. Med. Chem., 2013, 56, 2359-2373.（中国科学院一区，IF = 8.039）
(9) G. Jiang, L. Wang, H. Ye, H. Zou*, L. You*. Dynamic Covalent Reactions and Chirality Sensing with Diphenylethene Derived Hemiaminals. ChemPlusChem, 2023, e202300080. （中国科学院三区， IF = 3.21）
(10) Y. Hai,# H. Zou,# H. Ye, L. You*. Three switchable orthogonal dynamic covalent reactions and complex networks based on the control of dual reactivity. J. Org. Chem. 2018, 83, 9858−9869. （中国科学院二区，IF = 4.198）
(11) H. Lu, H. Ye, M. Zhang, Z. Liu, H. Zou and L. You*. Photoswitchable dynamic conjugate addition-elimination reactions as a tool for light-mediated click and clip chemistry. Nat. Commun. 2023, doi.: 10.1038/s41467-023-39669-x.
(12) C. Yin, H. Lu, H. Ye, Z. Feng, H. Zou, M. Zhang and L. You*. Double n→π* Interactions with One Electron Donor: Structural and Mechanistic Insights. Org. Lett. 2023, 25, 1470−1475.
(13) Q. Hu, Y. Liu, W. Li, Y. Wang, W. Liao, H. Zou, J. Li* , X. Huang*. Enhanced photocatalytic hydrogen evolution under visible-light using C, N Co-doped mesoporous TiO2 nanocrystals templated by ionic liquids. Chem. Eng. J. 2023, 451, 138670.
(14) Y. Hai, H. Ye, Z. Li, H. Zou, H. Lu, and L. You*. Light-induced formation/scission of C-N, C-O, and C-S bonds enables switchable stability/degradability in covalent systems. J. Am. Chem. Soc. 2021, 143, 20368–20376.
(15) S. Lin, J.-J Koh, T. T. Aung, F. Lim, J. Li, H. Zou, L. Wang, R. Lakshminarayanan, C. Verma, Y. Wang, D. T. H. Tan, D. Cao, R. Beuerman*, L. Ren*, S. Liu*. Symmetrically substituted xanthone amphiphiles combat gram-positive bacterial resistance with enhanced membrane selectivity. J. Med. Chem. 2017, 60, 1362-1378.
(16) J.-J Koh , H. Zou , D. Mukherjee , S. Lin , F. Lim , J. K. Tan , D.-Z. Tan , B. L. Stocker , M. S. M. Timmer , H. M. Corkran , R.Lakshminarayanan , D. T. H. Tan , D. Cao , R. W. Beuerman*, T. Dick*, S. Liu*. Amphiphilic xanthones as a potent chemical entity of anti-mycobacterial agents with membrane-targeting properties. Eur. J. Med Chem. 2016, 123, 551-556.
(17) D. Mukherjee, H. Zou, S. Liu, R. Beuerman, T. Dick.* Membrane-targeting AM-0016 kills mycobacterial persisters and shows low propensity for resistance development. Future Microbiol. 2016, 11, 643–650.
(18) J. Li , S. Liu , J.-J Koh, H. Zou, R. Lakshminarayanan , Y. Bai , K. Pervushin , L. Zhou , C. Verma , R. Beuerman*. A novel fragment based strategy for membrane active antimicrobials against MRSA Biochimica et Biophysica Acta (BBA)–Biomembranes. 2015, 1848, 1023-1031.
(19) J.-J Koh, S. Lin, T. T. Aung, F. Lim, H. Zou, Y. Bai, J. Li, H. Lin, L. M. Pang, W. L. Koh, S. M. Salleh, R. Lakshminarayanan, L. Zhou, S. Qiu, K. Pervushin, C. Verma, D. T. H. Tan, D. Cao*, S. Liu*, Roger W. Beuerman. Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant gram-positive bacterial infections J. Med. Chem. 2015, 58, 739-752
(20) J.-J Koh, S. Qiu, H. Zou , R. Lakshminarayanan , J. Li , X. Zhou , C. Tang , P. Saraswathi , C. Verma , D. T. H. Tan , A. L. Tan , S. Liu*, R. W. Beuerman*. Rapid Bactericidal Action of Alpha-Mangostin against MRSA as an Outcome of Membrane Targeting. Biochimica et Biophysica Acta (BBA) - Biomembranes 2013, 1828, 834-844.
(21) J.-J Koh, S. Liu , W. Zeng, H. Zou, L. Wang, V. Suresh, R. Beuerman*, D. Cao*. Electron donating group substituted and α-d-mannopyranoside directly functionalized polydiacetylenes as a simplified bio-sensing system for detection of Lectin and E. coli. Sens. Actuators B, 2013, 178, 563-571.
(22) L. Wang,* H. Zou, D. Ye, D. Cao Synthesis and spectra characteristics of novel 3-(para-Bromophenyl)-7-(substituted vinyl) coumarins. J. Heterocyclic. Chem. 2013, 551-556.
(23) W. Zeng , S. Liu , H. Zou, L. Wang, R. Beuerman*, D. Cao*. Synthesis of cationic diacetylene-co-carbazole-co-fluorene polymers and their sensitive fluorescent quenching properties with DNA. J. Polym. Sci. Pol. Chem. 2010, 314, 4168-4177.
(24) S. Lin, S. Liu, H. Zou, W. Zeng, L. Wang, R. Beuerman, D. Cao.* Synthesis of diketopyrrolopyrrole-containing conjugated polyelectrolytes for naked-eye detection of DNA. J. Polym. Sci. Pol. Chem. 2011, 3882-3889. (中国科学院三区，IF = 2.869)
(25) A. Fu,* H. Li, T. Chu, H. Zou, P. Feng, S. Yuan, Y. Duan. Theoretical studies of stereoselectivities in the direct anti-Mannich and Syn-aldol reactions catalyzed by axially chiral amino sulfonamide. J. Mol. Catal. A-chem., 2009, 314, 1-9. (中国科学院二区，IF = 5.089)
已申请专利
(1) Hanxun Zou, Rajamani Lakshminarayanan, Lei Zhou, Chang chui Charles Tang, Jun-Jie Koh, Donald Tan, Chandra Verma, Roger W. Beuerman, Shouping Liu, Padmanabhan Saraswath. Derivatives of Xanthone Compounds. Pub. No.: WO/2013/036207; International Application No.: PCT/SG2012/ 000328.（已授权）
(2) 尤磊、邹汉勋、叶何波. 一种荧光开关及其制备方法、应用。 专利号：201910092023.2 （已授权）
(3) 尤磊、海宇、叶何波、邹汉勋、陆涵葳、李紫毅. 二噻吩乙烯内酯类化合物以及制备、光调控方法。专利号：202110184683.0（已授权）
(4) 尤磊、姜国山、海宇、邹汉勋、环链异构二苯乙烯荧光分子以及制备方法、应用。专利号：202110184903.X（已授权）
(5) 尤磊、海宇、叶何波、邹汉勋、陆涵葳、李紫毅. 一种芳基乙烯内酯类化合物及其制备方法、应用。专利号：202110471450.9
(6) 尤磊、邹汉勋、冯泽林、陆涵葳. 一种脲化合物其制备方法、应用。专利号：202110443727.7
(7) 尤磊、邹汉勋、张翼. 一种基于1,8-萘二甲酰亚胺的水溶性荧光探针及其制备方法和应用。专利号：201910246470.9
(8) 尤磊、陆涵葳、叶何波、章梅兰、邹汉勋. 一种2-（乙氧基亚甲基）1,3-二酮二噻吩乙烯衍生物及其制备方法和应用。专利号：202210948443.8
(9) 尤磊、陆涵葳、叶何波、章梅兰、邹汉勋。一种二噻吩乙烯1,3-二酮化合物及其制备方法、应用。专利号：202210947333.X
联系方式
邮箱：zouhanxun@ptu.edu.cn
